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On the other hand, given the complexity of the identified multi-SNP-multi-trait patterns, it remains a challenge to convert this information into biologically meaningful interpretation.
The recent rapid growth of the number and diversity of sequenced prokaryotic genomes has led to a dramatic increase in the complexity of the identified cas gene arrays [ 24].
The complexity of the identified cholesteryl esters is in agreement with previous reports on cholesteryl ester content in human milk [ 30], though we were able to identify additional cholesteryl esters not previously described, possibly due to our one-step separation approach.
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Given the diversity and complexity of these identified signaling pathways associated with BRAF inhibitor resistance, fully defining the underlying mechanisms of resistance is still a priority to develop rational strategies to secure long-term responses of mutant BRAF melanomas to specific inhibitors.
Figure 19 reports the complexity of the classes identified in the present work.
The current understanding of breast cancer development supports this model, placing invasive cancer at the end of a multi-stage transition from normal breast epithelium; however, recent discoveries in molecular genetics and immunohistochemistry have highlighted the complexity of the process, identifying many different and divergent pathways resulting in invasive cancer.
These findings will help us study the contribution of the identified complexity in fault geometries and the geotherm in the volcanic areas to the revealed seismic process and consequently improve our understanding of the seismo-volcano tectonics.
These results indicate the remarkable potential of the "listening" brain and demonstrate the complexity of identifying the best-aided condition.
Because of the complexity of identifying the maximum of a scalar function in multi-dimensional space k-means clustering from an initial random seed inevitably reaches a local maximum rather than the global maximum.
The complexity of problems identified strongly suggests that children with chronic pain require pain clinics dedicated to the management of a wide spectrum of conditions to avert the considerable risk of developmental stagnation, misuse of analgesics and other associated problems of chronic pain.
This increases the complexity of identifying the presence of pain accurately in patients with dementia and raises questions about the validity of existing instruments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com