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However, the need to measure two photon fluxes simultaneously adds to the complexity of the experiment.
Reducing the complexity of the experiment reduces costs in terms of design, optimisation and manufacture.
Two rounds of orthogonal experiments were conducted to achieve a balance between the complexity of the experiment and the determination of the parameters.
To study the complexity of the experiment we specified a heteroskedastic logit model with the scale parameter specified as a function of the design dimensions.
Many theoretical and numerical studies exist in this domain, however, limited experimental investigations have been performed due to the cost and size related to testing facilities as well as the complexity of the experiment and related instrumentation.
They can quickly select the number of conditions and replicates and weight the number of samples and arrays in order to minimize the cost and complexity of the experiment as well as maximizing the efficiency of the experiment.
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Figure 8 Corresponding time complexity of the experiments in Figure 7.
Efforts are made to design a relatively simple model as compared to the high complexity of the experiments, applying simple mathematical sub-models with straightforward interpretations and enabling a numerically stable implementation.
Further comment from the scientists regarding Use Case 1: Screening a large number of compounds for binding affinity against a single protein can be carried out in vitro, but is both time-consuming and expensive given the cost of buying the compounds to screen and the complexity of the experiments required.
While using a matrix dramatically increased the complexity of the experiments and the difficulty in presentation, having the complete topologies permitted a global view and increased confidence and resolution.
The manuscript is extremely well written and easy to follow, which is especially commendable given the complexity of the experiments and the data.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com