Sentence examples for complexity of modifications from inspiring English sources

There are many challenges for the study of proteins in biological systems, including a broad dynamic range of expression, heterogeneity, complexity of modifications and many technical and preparatory steps prone to the introduction of bias.

However, while manipulation of the hPSC genome has become more routine in the last few years [ 27], engineering specific polymorphisms, deletions or amplifications is time consuming, requires a reasonable level of skill, and becomes increasingly challenging proportionate with the number and complexity of modifications required, even when nuclease-based methods are used [ 28].

"The technology used with servicing hasn't kept up with complexities of modifications and foreclosures".

These results demonstrate the complexity of epigenetic modifications and their interaction with age and sex.

Alternatively, the result may reflect the complexity of histone modifications in controlling gene expression.

Nevertheless, in this study, we took a step further by using five histone marks reported to be associated with enhancers in various studies and focusing on their combinations, our result highlights the complexity of histone modifications at enhancers and possibly other functional DNA elements.

Because of the size and complexity of the modification program, the administration has only recently assembled most of the pieces.

The natural coordination among different metabolic pathways contributes to the complexity of metabolic modification, which hampers the development of biorefineries.

In addition, lysines can be mono-, di-, or tri-methylated, whereas arginines can be mono- or di-methylated (symmetrically or asymmetrically), thus greatly extending the complexity of histone modification-dependent gene regulation.

Furthermore, the complexity of post-translational modifications of p53 needs to be taken into consideration to reveal the functional significance of the single modifications as well as the sequential interplay of different modifications [38].

Keeping in mind the low efficiency of the conventional top-down exfoliated 2D TMDs and the complexity of their surface modifications, we herein proposed a bottom-up strategy for the one-pot hydrothermal and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS2 nanosheets.