The actors move, often in unison, starting slowly and gradually increasing the complexity of combinations, building a limited physical vocabulary and then making the most of it.
Variable linking and relationships between cross-sectional area variables may greatly reduce computational complexity of combinations and multivariate rational function response surfaces can be built based on these relationships.
In light of the complexity of combinations of modified histones that decorate the genome, it is unlikely that these genes are "monovalent" as referred to previously [18] because monovalency would imply that they are not enriched in any other histone mark.
It is not the number of individual factors but the complexity of combinations that provides our 'human advantage'.
Although epidemiology remains at the core of such work, the increased complexity of combinations of interventions in public health has highlighted the utility of mathematical modeling for assisting in decision making and policy setting.
The complexity of combinations between the different Rabs and their myriad effectors is modulated further by two families of regulators: the GEFs (guanine-nucleotide-exchange factors), that promote GTP binding by Rabs, and the GAPs (GTPase-activating proteins), that trigger Rab GTPase activity and thus GTP hydrolysis to GDP.
Contributing factors for nonadherence may include patient age, drug tolerability, the largely asymptomatic nature of the disease, lack of patient education regarding adverse outcomes, and the complexities of combination drug regimens.
Recent genome-wide analyses of transcription factor binding have given insights into the complexities of combinations of transcription factors targeting lineage-specific genes (Wilson et al, 2010).
Diversity of expertise is considered important because of the complexity of the combination of relevant aspects, but is difficult to oversee for individual specialists.
The complexity of this combination approach underlines the importance of identifying suitable markers that can predict clinical benefit.
