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Tierra's platform will allow us to look for molecules which might otherwise be buried in the complexity of cells' metabolism," says Louis Metzger, chief scientific officer of Tierra, who comes from a background of drug discovery.
"There's a beautiful back-and-forth between biology and physics," Wirtz says, though 10 years ago he could not have predicted that because physicists had been reluctant to dive into the complexity of cells.
According to the size and complexity of cells, we identified two cell populations, of which one was bigger and more discrete (population 1, P1), while the other was relatively small and aggregated (population 2, P2) (Fig. 4A).
In contrast to the scarcity and complexity of cells from early stages of mammalian embryos, these cultures can provide large and highly homogeneous populations of cells at various stages of neural development, with the additional advantage of obtaining homogeneous populations of Sox1-GFP+ NPs by FACS sorting.
Potential explanations include the underlying complexity of cells, scalability and manufacturing concerns, and regulatory hurdles.
In the case of mammalian cells, the sensitivity against the pressure seems to be higher than the bacteria due to the structural complexity of cells.
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Many natural factors impede the effective conversion of biomass, such as the crystalline domains of cellulose, the structural heterogeneity and the complexity of cell-wall constituents as well as its complex cross-linking [ 15].
Single-cell genome sequencing reduces the sequence complexity of cell mixtures.
The existence of diverse regulated cell death pathways implicates the complexity of cell death programs but also provides novel therapeutic targets.
For years scientists had been puzzled by the chemical complexity of cell wall polysaccharides, which far exceeds the structural requirements of plant cell walls.
Our studies suggest specific biological roles for these molecules and reveal the complexity of cell fate regulation in embryonic stem cells.
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