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The peptides are transported between tissues and across the blood brain barrier via complex trafficking pathways [4].
However, Aβ has been shown to be a specific ligand for a number of different receptors and other molecules, transported by complex trafficking pathways, modulated in response to a variety of environmental stressors, and able to induce pro-inflammatory activities.
However, Aβ has been shown to be a ligand for a number of different receptors and other molecules [2], [3], [4], transported by complex trafficking pathways between tissues and across the blood brain barrier [1], [5], modulated in response to a variety of environmental stressors, and able to induce pro-inflammatory activities [6], [7].
Thus, defects in Ift88 or any one of the three USH1 proteins disrupt formation of the complex, trafficking, and biogenesis of the ERGIC (Fig. 6).
The Rab GTPase Ypt1p (orthologue of the mammalian Rab1) was among the strongest suppressors, restoring normal ER-to-Golgi complex trafficking and aSyn localization to the plasma membrane.
It therefore seems unlikely that the activation of JNK signalling is due to a generalized effect on ligand receptor complex trafficking or degradation.
Similar(50)
However, since the number of possible pairwise dependencies grows quadratically with the number of entities, the complexity is not manageable in the context of complex traffic situations.
You enter on a highly complex traffic gyratory system.
Belfiore recounts several low-impact crashes caused by the limited ability of current software to understand complex traffic situations.
The system is intended to reflect the complex traffic interactions that occur as traffic backs up on freeways and spills over onto city streets.
And, in the biggest deal, a few months ago, Intel paid fifteen billion dollars for Mobileye, an Israeli maker of digital-vision systems for navigating complex traffic environments.
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