Sentence examples for complex to spread from inspiring English sources

This then allows the Sir2/Sir3/Sir4 complex to spread outwards over neighbouring chromatin (Rusche et al, 2003).

Once recruited, Sir2 is thought to deacetylate the histones of adjacent nucleosomes allowing the Sir complex to spread outwards from the site of assembly [ 6, 7].

Thus, a positive-feedback loop based on cycles of histone H3 and H4 de-acetylation, Sir protein recruitment and O-AADPR-mediated stabilization allows the Sir complex to spread along subtelomeric nucleosomes and silence promoters kilobases away from Rap1-determined silencing nucleation.

Consistent with this notion, we found that several parB mutants, which are defective in the ability to form large nucleoprotein complexes and to spread from parS sites, fail to promote loading of Smc ScpAB onto the chromosome.

The MSL complex is able to spread long distances in cis from sites of roX RNA synthesis, and this has been taken as evidence that the MSL protein subunits begin assembling onto nascent roX transcripts cotranscriptionally [ 30- 33].

However, the RNA-induced transcriptional silencing (RITS) complex was shown previously to spread from siRNA-producing centromeric heterochromatin nucleation sites to regions with few or no siRNAs (Li et al, 2009).

An intrinsic oligomerization activity would allow PRC2 complexes to rapidly spread from their initial recruitment sites on chromatin, and may be a mechanism for the cell to rapidly establish de novo epigenetic silencing via a protein based positive-feedback clustering mechanism.

As costs went up and certain activities became more and more complex, they were spun out to spread expenses and know-how.

Hilary was a staunch defender of the military-industrial-intelligence complex at every turn, helping to spread the Iraq mayhem over a swath of violence that now stretches from Mali to Afghanistan.

Nevertheless, the relationship between epileptic activity and spreading depolarization is complex since the susceptibility to spreading depolarization is increased in acute epilepsy models but it seems to be strongly decreased in chronic epilepsy (Koroleva et al., 1993; Tomkins et al., 2007).

The steep increase actually began two years ago, primarily at the Rikers Island jail complex, then spread to clinics and hospitals.