T1R1 and T1R3 form a complex to sense the umami taste.
In young cells, but not in old cells, glutamate metabolism and transport (Fig 2 and additional file 4, 2E), as well as the signal transduction complex to sense extracellular osmotic stress and synthesize large amounts of trehalose (Fig 2 and additional file 4, 4E), were active during stationary phase and were down-regulated when cells were inoculated in fresh medium at a lower cell concentration.
BRCA1 associates with PCNA and the mismatch repair proteins MSH2, MSH6 and MLH1 to form the BASC complex, a genome-surveillance complex required to sense and repair DNA damages [ 47], thereby also playing a role in the MMR pathway.
Creatures with complex eyes to sense the light and the ability to seek shelter from the radiation for example, by migrating into deeper waters during the daytime would have been more successful.
The field, however, looks forward to challenges in global health, energy and the environment that could be well-served by carefully engineered microbes with more complex "programming" to sense and respond to variable and uncertain environments found beyond the bioreactor.
The Tsc1/2 complex appears to sense a large number of inputs such as the presence of growth factors, cytokines, energy stress and hypoxia, and integrates this information to regulate the activity of TORC1 via the GTPase Rheb [1].
There is remarkable diversity in the sensor proteins that form the inflammasomes, thus leading to the assembly of distinct complexes specialized to sense various signals.
The idea was either too simple or too complex to make any sense.
Thus, we currently favour the view that apical Spectrins act with Crb complexes to help sense forces by activating Hpo-Wts signalling during Drosophila wing and eye development.
TLR1, when associated to TLR2 (see below) in a heterodimeric complex, is able to sense triacylated lipoproteins purified from mycobacteria or synthetic peptides such as N-palmitoyl-S-dipalmitoylglyceryl (Pam3) Cys-Ser- Lys)4 (Cys-Ser- Lys
To successfully establish an infection, E. amylovora utilizes a complex regulatory network to sense the relevant environmental signals and coordinate the expression of early and late stage virulence factors involving two component signal transduction systems, bis- 3′-5′ -cyclic di-GMP (c-di-GMP), and quorum sensing [ 2– 11].
