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The reason is that a low threshold value will create a network highly connected which is too complex to manipulate and to visualize, whereas a high threshold value will lead to a graph with many connected components from which it will only be possible to infer time orders between connected genes.
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Technically, it refers to datasets that are too large and complex to manipulate or interrogate with standard methods or tools.
Methods to measure the kinetics of splicing, to observe the formation of the pre-spliceosomal complexes, and to manipulate and modify the in vitro system to resolve the regulatory influences in alternative splicing are presented.
Despite the complex bioinformatics expertise required to manipulate and interpret these massive data sets, only about half the respondents always or frequently consulted with a statistician when designing and analyzing a microarray study.
Summary: Assemble is an intuitive graphical interface to analyze, manipulate and build complex 3D RNA architectures.
The client provides a graphical interface to access, manipulate and execute complex queries by simple mouse clicking from the integrated database (the desktop client is illustrated in Figure 5).
The global system that encourages states to acquire nuclear weapons is complex and difficult to manipulate.
Prof Thorne said: "When Stephen lost the use of his hands and could no longer manipulate equations on paper, he compensated by training himself to manipulate complex shapes and topologies in his mind at great speed.
There is a growing literature that characterizes voting methods in terms of how computationally complex they are to manipulate.
Attachment of UM206 to magnetic nanoparticles (MNP) enables the ligand-MNP complex to be manipulated using magnetic fields, allowing control of Frizzled stimulation.
It may prove difficult to manipulate the complex and inter-related processes involved.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com