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Technically, it refers to datasets that are too large and complex to manipulate or interrogate with standard methods or tools.
The reason is that a low threshold value will create a network highly connected which is too complex to manipulate and to visualize, whereas a high threshold value will lead to a graph with many connected components from which it will only be possible to infer time orders between connected genes.
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Methods to measure the kinetics of splicing, to observe the formation of the pre-spliceosomal complexes, and to manipulate and modify the in vitro system to resolve the regulatory influences in alternative splicing are presented.
The global system that encourages states to acquire nuclear weapons is complex and difficult to manipulate.
There is a growing literature that characterizes voting methods in terms of how computationally complex they are to manipulate.
Attachment of UM206 to magnetic nanoparticles (MNP) enables the ligand-MNP complex to be manipulated using magnetic fields, allowing control of Frizzled stimulation.
The advances in computer techniques over the past decade have allowed Korot to manipulate complex patchworks of images in a single frame.
But now, a growing number of Europeans are convinced that the American system is both too complex and too easy to manipulate.
A 24-foot-wide screen provides a canvas for the video jockey, a visual artist with the hardware and software tools to manipulate complex 3-D animations on the fly -- and to the music's beat.
Prof Thorne said: "When Stephen lost the use of his hands and could no longer manipulate equations on paper, he compensated by training himself to manipulate complex shapes and topologies in his mind at great speed.
The latter provides immense resources for cloud users to manipulate complex datasets in applications [21].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com