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The interaction between PKM2 and β-catenin is required for this complex to interact with transcription factor 4 (TCF4) and to bind to the CCND1 (encoding for cyclin D1) promoter, which is likely guided by the associated β-catenin.
A shorter RNA may reduce the ability of the Cpf1 crRNA complex to interact with cationic lipids.
CRTC2, a master regulator of gluconeogenesis, competes with Sec23A, a subunit of the COPII complex, to interact with Sec31A, another COPII subunit, thus disrupting SREBP1 transport from the ER to the Golgi.
In the latter case, one would expect the SMC complex to interact with a specific chromosomal region.
Consequent activation of Wnt/β-catenin signalling allows the Tcf complex to interact with β-catenin, freeing it from an inhibitory state (Lepourcelet and Shivdasani, 2002).
Therefore, we assayed the ability of the wild-type phosphoparkin/phosphoubiquitin complex to interact with E2, or E2∼Ub (Fig 6D).
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A few recent publications describe the ability of various metal complexes to interact with RNA, and the binding of cisplatin and derivatives to RNA is being currently investigated.
The ability of the tested complexes to interact with sulfur-containing biomolecules (cysteine and reduced glutathione) at physiological levels was proved by electrospray-ionization mass spectrometry.
These studies have revealed that notwithstanding differences in drug pharmacokinetics, the activity of an ER ligand is determined primarily by (a) the impact that a given ligand has on the receptor conformation and (b) the ability of structurally distinct ER-ligand complexes to interact with functionally distinct coregulators.
The ability of the tested complexes to interact with sulfur-containing biomolecules (cysteine and reduced glutathione) at physiological levels was proved by ESI-MS experiments and the results led to the proposal of several possible mechanisms of direct interaction with biomolecules in relation to the cytotoxic action.
Pausing or rate reduction at unstable mRNA/DNA duplexes of 3'-UTRs and introns could give enough time to the processing complexes to interact with their corresponding mRNA elements and process the nascent mRNA transcript.
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