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When intracellular copper is chelated with neocuproine, a copper chelator that is effective at chelating copper but does not allow the TPEN-Cu complex to engage in redox reactions, TPEN becomes ineffective at producing ROS and killing colon cancer cells.
The jellyfish model cannot be fully evaluated in the context of the current EM data because we do not know the details of how the RRE fits into the structure, however the broader point that the NESs extend away from the Rev-RRE complex to engage Crm1 remains the simplest supposition and is entirely consistent with the EM data.
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This was dependent on endosomal maturation and the ability of the complexes to engage TLR signaling.
The necessity to complete 3′-processing may restrict the ability of incompletely assembled viral nucleoprotein complexes to engage target DNA and perhaps reduce the chance of suicidal auto-integration.
Simple enough to suit young singers yet complex enough to engage them, Mr. Moran's elegant, potent writing was pitched perfectly to the occasion.
After the original study ended, the ACT teams continued to acquire patients from the original REACT study sample who were allocated to CMHT care, whose needs were complex (difficult to engage in treatment and requiring recurrent admissions due to the severity of their symptoms and risk profile) and to transfer or discharge those who had stabilised.
The above data support a model where TPEN induces selective death of cancer cells through its ability to chelate copper away from cellular proteins, resulting in the formation of a TPEN-copper complex able to engage in redox cycling thus generating ROS and inducing cell death.
The same type of distribution has been observed in previous studies in both mammalian and insect cells [for example 23], and is explained by the fact that many Pol-II complexes fail to engage in efficient elongation.
The United States will find it steadily more difficult and complex to either engage or disengage in the Middle East, in pursuit of energy independence or political stability or the war on terrorism, because oil from the gulf will become steadily more indispensable to the American economy, barring a wholesale change in the way the nation uses energy.
The systematic effort toward comparative work on appropriately defined Zn II) species and insulin in inducing adipogenesis reveals the salient structural features in the Schiff family of ligands configuring Zn II) so as to promote complex formation sufficient to engage biomolecular targets during the process of initiation and maturation.
Sharks often employ complex hunting strategies to engage large prey animals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com