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The genes in this subclass have been suggested to function in the same pathway or complex to confer fluoxetine-induced nose contraction (Choy & Thomas, 1999).
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However, we must still investigate whether similar elicitors exist in V. dahliae and how the FLS2– BAK1 complex acts to confer pathogen immunity in resistant cotton plants.
Nevertheless the chemical industries nowadays are increasingly involved in specialty chemicals (small quantity, batch production, high added value) as well as formulated products (complex mixtures targeted to confer specific end-use properties).
The alleles of this complex have been found to confer a predisposing effect, a neutral effect, or a protective effect in rheumatoid arthritis [ 24].
Conversely, a chromatin-modifier complex has recently been shown to confer reprogramming resistance to imprinted regions in a global, but much more specific manner.
However, traits can also be stacked to confer more complex characteristics, and some traits can even be up-regulated using TILLING by targeting genes that code for inhibitory factors.
It should be noted that reduced degradation of the IKK complex may not be sufficient to confer NF-κB activation and that it has been proposed that hypoxia does not play a major role in the activation of NF-κB [ 168].
The precise subunit composition of these complexes can be fine-tuned to confer functional specificity within the cell.
BAF250a has a DNA-binding domain that specifically binds to AT-rich DNA sequences and is thought to confer specificity to the complex [Wu et al., 2009].
The ER/AP-1 complex can confer estrogen responsiveness to additional subset of genes found in our dataset such as: ovalbumin (Fold change: 3; p = 0.033) and c-fos (Fold change: 2.1; p = 0.033); two transcripts detected as over-expressed in ERα breast tumors by SAGE (additional data file 1).
In C. elegans, mammalian cells and Drosophila, HDAC-containing complexes also confer repressive functions to the LIN-1/ETS/Yan transcription factors that are bound to target genes, and their actions are antagonised by signalling input from the EGF/Ras/RTK pathway.
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