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Prolonged inactivation of TORC1 by rapamycin potentially leads to a shift of mTOR from the TORC2 complex to being rapamycin-bound, and lead to decreased Akt activation, activation of GSK-3 β (which regulates cyclin D1 proteolysis, and enhances rapamycin-mediated growth inhibition), and apoptosis.
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The law is complex, to be sure.
Worse, they were too complex to be fully understood.
Issues are too complex to be evaluated this way.
The take-home message here is complex, to be sure.
Today, many residents consider the complex to be run efficiently.
Has enterprise software become too complex to be effective?
It is too richly complex to be used as wallpaper and subordinated to what is seen.
Besides, she says, African history is too complex to be embraced as a generality.
Real engineering problems are too complex to be addressed in this way.
Again, life is far too complex to be predicted with any consistency.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com