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This property is of immense practical relevance since most real signaling cascades are too complex to be translated into a complete mechanistic model which is subsequently reduced.
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This makes joining distributed data more complex, because pseudonyms need to be translated from one namespace into another namespace.
Despite the considerable evolutionary distance between human and yeast, analysis of patient mutations in Y. lipolytica has the potential to be translated to human complex I biology.
In turn, x2 can be the target of another RNA species u2 (and form an inactive complex to be degraded) or it can be translated into protein x3.
Rather, the output of complex models must be translated into meaningful parameters and simple instructions that are useful to forest managers.
Since the frequency at which a given Ag is presented depends on its effective abundance, this minimum number of MHC-peptide complexes can be translated into an effective abundance threshold a* (see Methods).
Concrete illustrations are given of how the essence of quite complex basic theory can be translated into a simpler representational format to help clinicians conceptualise a psychopathological state and pinpoint relevant variables that might be changed by therapeutic interventions.
Besides being some outright impressive work, the concept art is a shining example of how well even the most complex of artistic visions can be translated to the big screen.
This analysis also illustrates how complex biochemical signals can be translated into cell fitness that determines disease dynamics.
Nevertheless, the two complexes are thought to be similar enough that general conclusions might be translated from one complex to the other.
Accordingly, application of this model shows that insights gained from 2D melanoma culture cannot readily be translated to complex 3D skin-melanoma models, and it implies that the tumor environment decisively impacts the response to therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com