Furthermore, the increased tendency of OXPHOS complexes to aggregate, including the observed oligomerization of the ATP synthase complex, as well as the important change occurring in membrane lipid composition with age [ 39, 40], might be at the basis of the supramolecular changes [ 41- 43].
This complex tends to aggregate more easily due to changing the secondary structure of A β towards β-sheet formation [ 169, 170].
During the interaction and diffusion phases, small complexes start to aggregate till the pseudocell reaches an equilibrium state in which the emerged complex structure remains stable.
Polymer-based DNA complexes based on poly- l-lysine (PLL) and polyethyleneimine (PEI) products protect plasmids from nuclease digestion and facilitate cellular uptake; however, when used in vivo, these complexes tend to aggregate and accumulate in different tissues.
Moreover, putative loss of function variants of APH1B, a crucial component of the γ-secretase complex, were found to aggregate with NRG1 risk alleles in schizophrenia patients (Hatzimanolis et al., 2013) and Aph1b-loss of function mutations in rodents display behavioural phenotypes that are relevant for schizophrenia (Coolen et al., 2005, 2006; Dejaegere et al., 2008).
In mammalian cells, a high proportion of RNA-binding proteins found in RNP granules contain LC domains that are necessary and sufficient to transform RNP complexes from soluble to aggregate states (Kato et al. 2012).
In animals and yeast, signaling complexes have been shown to aggregate into lipid microdomains termed "lipid rafts" [5], [6].
One of these approaches is to aggregate all complex results into a single large-scale indicator, the chemical footprint.
It is deduced that due to the coordination between the Zn 2+ and QDs, the Zn (MPA) complex acts as a flocculant to aggregate the synthesized QDs in water at the elevated temperature.
It is particularly efficient for complex OLAP queries that need to aggregate large portions of the data warehouse, such as "report the total sales in all stores located in California and New York during the months February May of all years".
Using a standard in vitro angiogenesis assay of endothelial cell tube formation, conditioned media from PHD2 knockdown HCT116 cells were able to cause primary endothelial cells plating on matrigel to aggregate, forming complex, tube-like structures.
