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Alternatively, the altered Duo1 product may interact differently with the complex to affect the regulation of microtubule-binding.
Whether the PP2A may regulate Aurora-A and KSR complex to affect the MEK/ERK signaling pathway is valuable to explore.
Based on the sequence similarity between the conserved DLNQIP sequence and the EAR-motifs of class II ERFs, RAP2.1 may also recruit such a co-repressor complex to affect repression.
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Some studies have shown the ability of Cu humic complexes to affect Cu uptake by plants cultivated in silica sand [24 27].
In this work, we tested the potency of curcumin CD complexes to affect growth of lung tumours orthotopically implanted in mice.
Similar to a lot of other proteins exhibiting extended superhelical structures, LRPPRC may simply serve as a scaffold protein to facilitate assembly of different functional protein complexes to affect multiple cellular processes.
Several studies suggest that many lncRNAs can be associated with chromatin-modifying complexes to affect epigenetic information and to confer multiple properties that are required for tumor progression and a metastatic phenotype [ 10- 12].
Evidences suggested that one of the major roles of lncRNA was to guide the site specificity of chromatin-modifying complexes to affect epigenetic changes [ 21]. lncRNA could regulate gene expression at transcriptional and posttranscriptional level by targeting either local or distant genes [ 23].
Moreover, DNA methylation interacts with other epigenetic marks in a complex manner to affect transcription and regulate gene expression [ 21, 75].
Geographical work has emphasised that a multitude of social, cultural, political and economic factors interact in complex ways to affect alcohol consumption, across spatial scales from the global to the local (Jayne et al., 2008).
A single gene could have a dynamic profile across different treatment conditions (a combination of assay, dose and time point) with a role in multiple pathways which interact in complex manners to affect physiological changes of toxicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com