Sentence examples for complex polygenic disorders from inspiring English sources

However, within the last few years rapid advancements have made genome-wide association (GWA) studies feasible and these studies have provided new insight into the pathogenesis of a number of complex polygenic disorders.

While evolutionary analysis of coding SNPs (cSNPs) within conserved amino acid sequences is informative most often for monogenic and Mendelian diseases, the same approach holds less utility in the analysis of complex, polygenic disorders due to association of many low-risk non-coding SNPs.

GWASs have been successfully applied to complex polygenic disorders, such as diabetes and macular degeneration.

In addition, for some of the more complex polygenic disorders, patient-specific iPSCs also proved to be useful models of disease progression.

Consequently, there is considerable potential for CNVs to play a significant role in susceptibility to infection and they could, to some extent, explain the variable penetrance of inherited complex polygenic disorders such as autoimmunity.

They are believed to be complex, polygenic disorders predominantly characterized by multifactorial inheritance [ 1], although Zhao et al. [ 2] (2007) suggested that Mendelian inheritance may apply to autism risk in a subgroup of families with affected males.

Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder.

Type 2 diabetes is a complex polygenic disorder characterized by the presence of insulin resistance and pancreatic beta cell dysfunction.

It has an estimated heritability of approximately 76% and is thought to be a complex, polygenic disorder [ 2].

It has an estimated heritability of approximately 76 percent and is thought to be a complex, polygenic disorder [ 2].

AD is a complex polygenic disorder with lack of understanding of natural course of the disorder and absence of reliable biomarkers that can predict disease onset and progression.