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It is the result of a complex pathogenic pathway that culminates in autoantibody formation (Yeoh et al., 2018).
This phenomenon is likely explained by the complex pathogenic process of inflammation and innate immunity in the development of gout since the MSU crystal-mediated inflammatory pathways have been reported to associate with many immunological processes (Behrens et al., 2008).
Group A Streptococcus (GAS) causes a diverse array of human infections and sequelae, and exhibits a complex pathogenic behavior.
Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is widely used to investigate complex pathogenic mechanisms.
Bronchopulmonary dysplasia and respiratory distress syndrome of preterm infants have complex pathogenic mechanisms.
This may arise from complex pathogenic mechanisms, which result in decreased matrix synthesis and upregulated pathways of tissue degradation [ 3].
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Several species of this complex are pathogenic to humans.
In our earlier studies, we have established an important paradigm with respect to M. avium complex that pathogenic adaptations in MAC, unlike in the organisms of M. tuberculosis lineage, are not exclusive to the selective deletion events as shown by a congruent RD (region of deletions) profile across the pathogenic and saprophytic lineage of genus Mycobacterium [38].
Treatment was complex: antibacterial, pathogenic and symptomatic.
Our results imply that reduced catalytic activity of the NatA complex is pathogenic.
Irrespective of the gene involved, neuropathological features argue for more complex underlying pathogenic mechanisms and are summarized in Table 1.
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