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Titin molecules are crosslinked in an antiparallel palindromic complex of domains Z1-Z2 and the small Z-disk protein telethonin (Zou et al., 2006).
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Johansson T, Pedersen A, Leckner J, Karlsson B.G, 2005, Complex of the domain I and domain III of Escherichia coli transhydrogenase, 2BRU ; http://dx.doi.org/10.2210/pdb2BRU/pdb, Publicly available at the RCSB Protein Data Bank.
The second, is the vacuolar (V) H+ATPase, a complex of two domains, V1 (8 subunits) and V0 (6 subunits), which is responsible for the active transport of protons from the cytosol into the vacuolar lumen [ 49].
Here, the complex of the domain of is a little bit more complicated.
The complex of TCR Vβ domain specific for the hemagglutinin antigen peptide (HA) with HLA-DR4 (PDB code: 1j8h) was selected for this purpose.
Some distance away from the decoding site are a number of other SSU universal proteins that have a complex of cellular domain-specific blocks in both Bacteria and Archaea.
Thus, there seems to be a complex interplay of domain tethering, quaternary states and function.
For most UMLS semantic relations there is a quite complex arrangement of domain and range restrictions, in which certain range restrictions are only valid with certain domain restrictions.
The orientation of D3 relative to D1 would allow a contiguous stretch of CR domains to bind in the same manner as in the two complexes of isolated domains.
Indeed, vesicle template assembly has been successful for assembly of functional complexes of cytoplasmic domains of other membrane proteins such as receptor kinases.
The substrate analog-bound structures that represent the biologically relevant complexes of proofreading domains invariably occupy the deepest available pocket having a striking surface complementarity.
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