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Discordances between protease inhibitor interpretations resulted from a larger number of more complex mutation patterns.
Conclusions: A complex mutation of hMLH1 at codon 226 is associated with adolescent onset of colorectal cancer in an HNPCC family.
The color pattern of the Appaloosa is of interest to those who study equine coat color genetics, as it and several other physical characteristics are linked to the leopard complex mutation (LP).
A recent study has demonstrated conference of metastatic potential by ND1 complex mutation through ROS generation in a tumor specific fashion [37].
Further, the ability to target separate mutation profiles to any number of regions along the gene allows emulation of complex mutation phenomena like hotspots.
Thus, the system must also be able to identify these complex mutation expressions.
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More complex mutations involved missing or extra sequences of DNA.
Large deletions and complex mutations account for 23%.
The occurrence of non-random genetic changes in hPSC cultures is now well established, but the genetic roadmap that leads to the complex mutations remains obscure.
Increased expression of beta-catenin may be due to factors such as mutations in beta-catenin, abnormalities in the beta-catenin destruction complex, mutations in APC, overexpression of WNT ligands, and loss of inhibition or decreased activity of regulatory pathways.
The MAP assay is exquisitely selective for MIDIs and other complex mutations.
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