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The approximate dissociation constant (KD) of 62 nM for the enzyme-methotrexate (NSC740) complex matches reported literature values, which range from 2 to 50 nM [20 22], within experimental error.
Next, only novel predictions are kept: if any predicted complex matches any reference complex with match_thres = 0.5, then that predicted complex is removed.
In our experiments, ω is set as 0.20 to evaluate if a predicted complex matches with a gold standard protein complex (see equations (4) and (5)).
We derive 408 typical complexes including two or more proteins from the CYC2008 [ 35] as the benchmark complex set and use the same scoring scheme used by [ 14] to determine how effectively a predicted complex matches a reference complex.
When the miRNA (or siRNA, respectively) contained in the complex matches perfectly to its target mRNA (usually in the mRNA's 3′-UTR), an RNA-induced silencing complex forms, and Ago cleaves the target mRNA opposite to the miRNA.
Scrutiny revealed that SORTA was able to find the complex matches, where data values and ontology terms consist of multiple words, and some of which are concatenated, e.g. matching 'propionic acidemia' from DO with 'Propionicacidemia' from HPO.
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The matching technique: Most systems use complex matching techniques, mainly to extract a melody out of polyphonic melodies.
This model more closely captures the often complex matching properties of real rock fractures than previous more simplified models.
Slightly fizzy, pear-scented and steely, the 2009 Perlant ($16.99) is a subtly complex match par excellence for oysters and clams.
Entity Resolution (ER) matches and merges records that refer to the same real-world entities, and is typically a compute-intensive process due to complex matching functions and high data volumes.
— Leaders in the field of kidney transplantation recommended last week that a single nationwide registry should oversee the complex matching process needed to expand the use of transplant chains and other forms of paired donation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com