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For the past several years my laboratory has studied the genetics of complex human disorders, those disorders that fail to show a Mendelian pattern but do "run in families".
Especially, Dr. Zheng have been developing statistical and computational tools for high dimensional data, searching for genetic interactions associated with complex human disorders, quantifying social structure and studying hard-to-reach populations using survey questions, with more than 40 peer-reviewed publications in journals including JASA, AOAS and PNAS.
For example, alteration of KCNMA1 function has been associated with several complex human disorders including cancer.
Overall, this study outlines the potential of systems biology to uncover links between genetics and pathogenesis of complex human disorders.
Our data suggest that the involvement of the EGF pathway in the pathogenesis of various complex human disorders may be genetically determined.
Overall, our data indicate that the genetic framework predisposing to complex human disorders may contribute to changes in these basic cellular functions.
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The reconstruction of the molecular framework hosting genetic variants associated with susceptibility to a complex human disorder has the potential to reveal the biological mechanisms underlying that disease and to highlight similarities with other diseases.
Alcoholism is a complex human disorder with biomarkers for neural health dysfunction that are now detectable with neuroimaging methods.
However, a comprehensive collection of terms that is relevant for a complex human disorder with broad clinical manifestations, such as ASD, is a major challenge.
UCMS is a behavioral paradigm that robustly increases behavioral emotionality, thus presenting some homologous features associated with human depression (although not 'modeling' this complex human disorder, but providing critical information about the system under chronic stress conditions) [ 40].
However, some genes identified in animal models have contributed to an improved understanding of complex human behavioral disorders such as reading disability, hyperactivity, autism, and dementia.
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complex human problems
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complex mental disorders
complex neurodevelopmental disorders
complex multifactorial disorders
complex polygenic disorders
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complex neurodegenerative disorders
complex haemodynamic disorders
complex human rights
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complex human diseases
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