Sentence examples for complex human disorder from inspiring English sources

The reconstruction of the molecular framework hosting genetic variants associated with susceptibility to a complex human disorder has the potential to reveal the biological mechanisms underlying that disease and to highlight similarities with other diseases.

Alcoholism is a complex human disorder with biomarkers for neural health dysfunction that are now detectable with neuroimaging methods.

However, a comprehensive collection of terms that is relevant for a complex human disorder with broad clinical manifestations, such as ASD, is a major challenge.

UCMS is a behavioral paradigm that robustly increases behavioral emotionality, thus presenting some homologous features associated with human depression (although not 'modeling' this complex human disorder, but providing critical information about the system under chronic stress conditions) [ 40].

For example, alteration of KCNMA1 function has been associated with several complex human disorders including cancer.

Overall, this study outlines the potential of systems biology to uncover links between genetics and pathogenesis of complex human disorders.

Our data suggest that the involvement of the EGF pathway in the pathogenesis of various complex human disorders may be genetically determined.

Overall, our data indicate that the genetic framework predisposing to complex human disorders may contribute to changes in these basic cellular functions.

In conclusion, in this article we provided an unprecedented comparison among the genetic interactomes derived from genes predisposing to five complex human disorders.

A more long-term goal is to assemble and cross-validate a reliable and comprehensive map of human interactions, to enable diagnosis and treatment of complex human disorders [25].

Although a few previous studies revealed enriched biological pathways related to susceptibility genes in several complex human disorders, including MS [10], [13] [15], no information was available on pathways emerging from the global genetic framework.