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Future epigenetic studies investigating the origins of complex human disease will therefore need to incorporate multiple-level systems modeling and complexity science to uncover disease etiology in complex and dynamic biologic systems.
A key challenge in precision medicine lies in understanding molecular-level underpinnings of complex human disease.
Great efforts and expense have been expended in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease.
Both to review the success of the positional cloning paradigm as applied to complex human disease and to investigate the characteristics of the whole-genome scans undertaken to date, we created a database of 101 studies of complex human disease, which were found by a systematic Medline search (current as of December 2000).
However, the success of positional cloning attempts based on whole-genome screens has been limited, and many of the fundamental questions relating to the genetic epidemiology of complex human disease remain unanswered.
We believe that, as a newly emerging methodology, the meta-analysis approach has the potential to become an integral part of our toolbox that will expedite the search for complex human disease genes.
Similar(5)
Genetics of complex human diseases : a laboratory manual / edited by Ammar Al-Chalabi, Laura Almasy.
Kanai M. et al. Genetics of quantitative traits in the Japanese population links cell-types to complex human diseases.
Li, Y. & Kellis, M. Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases.
The MARVEL domain appears to be related to complex human diseases, such as schizophrenia and inflammation.
Genomewide association studies are being conducted to unravel the genetic etiology of complex human diseases.
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