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In addition, meditation and yoga can boost immunity, and regular practice seems to promote more complex genetic effects related to healthier aging.
Complex genetic effects might likewise contribute to the observation that some of the complemented mutants tested showed only incomplete recovery of the wild type virulence phenotype.
Recent technological advances in genomics coincide with increasing recognition of the importance of very large cohorts for studying complex genetic effects [22].
These updates also make possible future extensions of BOADICEA to model more complex genetic effects.
Many complex genetic effects, including epigenetic effects, may be expected to operate via mechanisms in the inter-uterine environment.
EMIM is primarily designed for the investigation of complex genetic effects, including maternal genotype effects, maternal fetal interactions and imprinting (41).
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To test for a more complex genetic effect of variants of the candidate genes, we performed an association study.
In the analysis of complex traits, genetic effects can be confounded with non-genetic effects, especially when using full-sib families.
Given that WNT signaling involves a large variety of gene products, there is likely to be a complex genetic background effect in human populations in response to environmental endocrine disruptors.
These data may highlight the complex nature of genetic effects within GBMs which are not derived from a single gene but rather a complex reprogramming of hundreds of genes being dysregulated.
Thus, besides Mendelian (single) genes, also complex (multi-gene) genetic effects need to be analyzed to understand the full repertoire of host responses to pathogens.
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