Approaches to the study of common, complex genetic disorders like attention-deficit/hyperactivity disorder (ADHD) are evolving rapidly.
Furthermore, we examine the similarities of six complex genetic disorders at the SNP-level, gene-level, gene-cluster-level, and pathway-level.
Enabled in part by these awards, I developed systems medicine methods for comparative network analysis, including approaches in game theory, that significantly improve signal detection for complex genetic disorders such as autism.
Prior to coming to Columbia, I earned a Bachelor of Science degree from the University of Vermont, where I conducted research on the relationships between phylogenomics and complex genetic disorders under the advising of Dr. Neil Sarkar.
The contributions provide in-depth analyses of a broad range of neurodevelopmental disorders, including those resulting from whole chromosome defects (Down and Turner syndromes), those related to defects in a single gene (fragile-X syndrome) or a small number of genes (Williams syndrome), and complex genetic disorders (dyslexia, autism).
Topics include: genetic and environmental risk factors for complex genetic disorders; design and interpretation of genome-wide association studies; pharmacogenetics; full genome sequencing for disease gene discovery; population structure and genetic ancestry; use of personal genetic information in clinical medicine; ethical, legal, and social issues with personal genetic testing.
