Sentence examples for complex genetic aberrations from inspiring English sources

Previous studies have revealed complex genetic aberrations affecting almost all chromosomes with up- and down-regulation of several genes in this subtype of CTCL.

Of note, p53strong cases were only found among the SOX11low subgroup, indicating that these may constitute cases with more complex genetic aberrations, consistent with a shorter survival.

Lack of an association may be due to the different histological types from which the cell lines originate (Squamous carcinoma, Adenocarcinomas and Adenosquamous carcinomas) with complex genetic aberrations.

Sensitivity varied in a range from 2.6 to 12.5 μM in patient-derived cell lines, without any remarkable difference either among the tumour histotypes nor in sarcomas carrying specific translocations or displaying complex genetic aberrations.

Despite a similar trend, a statistical correlation was not observed between IgH and BCL2 expression in grade 3 FL, possibly because of the relatively low number of cases analyzed or to a different biology of grade 3 FL, which typically have an increased number and complex genetic aberrations as compared with grade 1 and 2 FL.

This has revealed a new complex landscape of genetic aberrations where addition of mutations in epigenetic regulators has been one of the most important contributions to the understanding of the pathogenesis of AML.

Especially in molecular level, tumours of the same category can appear significantly dissimilar due to complex combinations of genetic aberrations leading to a similar malignancy.

Glioblastomas are characterized by complex genetic and epigenetic aberrations that differ between primary and secondary glioblastomas but affect a similar set of pathways, in particular receptor tyrosine kinase/Ras, phosphoinositol 3-kinase, p53 and pRb signalling (TCGA, 2008).

The complex interplay between EBV and genetic aberrations in nasopharyngeal epithelial cells during tumor initiation and progression poses great challenges to NPC research [44].

Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple genetic aberrations.

This suggests a more complex genetic background for astigmatism than for spherical aberrations.