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However, we cannot distinguish whether separate WRN molecules engage the junction, or if different WRN monomers of a higher oligomeric complex engage the junctions.
Hence the TPEN-Fe and TPEN-Cu complex engage in redox cycling resulting in the generation of ROS.
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The architecture of the intact cellulosome of Clostridium thermocellum, a huge extracellular multi-polypetide bacterial enzyme complex engaged in degradation of cellulose, was investigated by electron microscopy.
Evidently, the αCTD in the Spx-αCTD complex engages the trxB promoter DNA in a manner that is different from its interaction with the UP element, as Spx is unable to contact αCTD on the spoVG promoter fragment.
Likewise, the identification of a p55γ-containing PI3-K complex engaged by β1 integrin/Fak-mediated signaling is novel.
The next challenge is to determine the structure of the fully open complex engaged in secretion or with a membrane protein trapped during the insertion process.
Ctf4 is an integral component of the replisome progression complex, engaged in protein interactions between the MCM DNA helicase, the GINS complex and the DNA polymerase α/primase complex.
The p75NTR sortilin receptor complex engaged by proNTs essentially initiates the opposite signal (death vs. survival) to that of the classic high-affinity Trk receptors, which are receptor tyrosine kinases (Lewin & Barde, 1996; Reichardt, 2006).
Since degradation of the ATPase defective Cdc6-E224Q, Cdc6-E224G and Cdc6-N263A mutant proteins after MCM loading promotes DNA replication, Cdc6 ATPase activity is required for Cdc6 release from the pre-RC, that is, an ORC-Cdc6 intermediate complex engaged with MCM (see model in Figure 5C).
These experiments show that MSL and NSL complexes engage in the regulation of thousands of genes.
showed that nucleosomes are repositioned more efficiently when two ACF complexes engage with a single nucleosome (Racki et al., 2009).
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