Sentence examples for complex dysfunction from inspiring English sources

These findings build on emerging evidence for altered brain mechanisms of auditory scene analysis and suggest complex dysfunction of network hubs governing the interface of internal milieu and external environment in AD.

A complex dysfunction in orexins transmission may also explain the correspondence between lack of sleep and altered modulation of pain with central sensitization facilitation.

Thus, how is E-cadherin/catenin complex dysfunction able to activate EGFR signaling and how can loss of CDH1 function explain above signal perturbation and drug phenotype?

Since DAF-28/insulin secretion in this way is sensitive to TOMM complex dysfunction, we conclude that mitochondria in general and the TOMM complex in particular are required to couple food signals to secretion of DAF-28/insulin.

Nonetheless, this impairment in prosodic production may stem from a more complex dysfunction concerning prosodic perception, which would be in line with the hypothesis that an abnormality of sensory integration processing would be the core of autism [17].

Thirdly, leukostasis has been found to correlate with inter-endothelial tight junction complex dysfunction and disorganization.

Additionally, frequent epigenetic aberrations such as IDH1/2 mutations and switch/sucrose non-fermenting (SWI/SNF) complex dysfunctions suggest that epidrugs must also be considered.

The type and location of most of the previously described mutations in the endoglin (ENG) gene suggested a dominant-negative model of receptor-complex dysfunction for the molecular basis of this disorder.

Indeed, the extent of volatile anesthetic hypersensitivity directly correlates with the degree of complex I dysfunction in C. elegans, rather than with dysfunction of any other respiratory chain complex [13].

Whereas deficiencies in respiratory complexes I, III, V or CoQ increased cellular ROS levels and induced oxidative damage, complex IV dysfunction did not promote ROS generation, and the cell death induced by COX dysfunction was rather due to the increased susceptibility of these cells to additional (environmental) stress cues.

Systemic erythematosus lupus (SLE) affects multiple organs and involves complex immune dysfunction.