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Significant correlation between mercury and methyl mercury concentrations reflect beginning the detoxification process and proceeding of Hg MeHg complex, detoxification process is under the influence of species type, tissue properties, chemical form of methyl mercury and mercury, and the exact mechanism are not apparent (Pirrone et al. 2001; Cheng et al. 2011).
E. coli uses a complex detoxification pathway to protect against the oxidative stress posed by reactive oxygen species (ROS), including oxygen ions, free radicals, and peroxides [28].
These studies represent the promise of a greater understanding of the role of NTSR genes in complex detoxification pathways associated with herbicide resistance.
For example, this should improve the efficiency of resistance diagnosis, the knowledge of complex detoxification pathways associated with NTSR and the capacity to design successful treatment strategies for multiple targets.
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These cysteine-rich peptides derived from glutathione (GSH) are synthesised in response to heavy metals to chelate them intracellularly and important constituents of the complex metal detoxification systems of higher plants, algae and some fungi.
Complex arrays of detoxification mechanisms have been selected in plants against ROS accumulation and toxicity.
These cells perform complex metabolic and detoxification functions in vivo and tend to rapidly lose their ability to perform these functions in vitro.
Of the 373 GO biological processes and 383 pathways, over 80% are involved in the known liver-related biological functions, such as metabolic function, bile secretion, lipid transport and homeostasis, cholesterol homeostasis, regulation of blood coagulation, protein-lipid complex subunit organization, detoxification, Immune defense and complement activation.
Based on the determination of Cd bioaccumulation in fish and the complexing stability constant of Cd-BTR complex in solution, the detoxification mechanism of co-existing 1H-BTR on Cd to the zebrafish was discussed.
It seems that a hydrolytic detoxification of complex 1 leads to a lower effective dose of the active substance on the one hand.
They stated that the ability of plants to create high molecular weight (HMW) complexes through medium molecular weight (MMW) complexes from low molecular weight (LMW) complexes is more productive for detoxification of toxic metals than for synthesis of longer PCs [ 7].
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