Recent progress in SPR MS includes improved methods and operations, increased limits of detection, multi-protein analysis and protein-complex delineation.
The relative importance of different P2 receptor subtypes present in smooth muscle for contraction is complex and delineation of the contributions of specific subtypes complicated by the lack of highly selective agonists/antagonists. Available data suggest that G protein-coupled P2Y2, P2Y4, and P2Y6 receptors, and ionotropic P2X1 receptors contribute to nucleotide-mediated contraction.
In topographically complex landscapes, this delineation is constrained by digital elevation model (DEM) resolution and the influence of microtopographic features.
In mixed-species forests of complex structure, the delineation of tree crowns is problematic because of their varying dimensions and reflectance characteristics, the existence of several layers of canopy (including understorey), and shadowing within and between crowns.
From an outstanding paper I would expect either a systematic and unbiased approach to identifying the substrates of the putative chaperone complex or a delineation of the features that it recognizes in its substrates or some direct evidence for the actual chaperone activity proposed.
Riparian boundaries are complex to delineate and characterize, with a multitude of variables available for delineation.
Her work garnered critical huzzahs right out of the gate for its clear, unfinicky delineation of complex adult emotions.
Genome profiling techniques provide a readily accessible platform for the delineation of complex rearrangements at the breakpoint level, thus allowing the study of the molecular mechanisms underlying such rearrangements.
To allow gene expression profiling of different marmoset organs and delineation of complex biological pathways, we have developed a marmoset-specific DNA microarray, called EUMAMA (EUropean MArmoset MicroArray) starting from large scale EST sequencing of marmoset transcripts to generate the required sequence information.
These molecules act as molecular switches and also as sites for assembly of supramolecular complexes, making the precise delineation of function more challenging.
