The majority of cancers have a complex causation with a number of environmental factors acting on an individual's genetic background to influence risk.
His discussion of the "blame instinct", for example, is important because it reminds us of people's impatience with complex causation and tendency to pin everything on one agent.
Moreover, complex causation is often a weak causation.
The complex multigenic causation of human NTDs, together with the large number of possible candidate genes, has hampered efforts to delineate their molecular basis.
This information may help the investigator avoid needlessly speculative or complex hypotheses about the causation of personality traits when simple explanations might be superior.
There is increasing evidence that regulatory activity at the level of DNA methylation plays an integral part in the causation of complex human diseases, including cancer, neuronal diseases, diabetes and obesity [ 24- 28].
Before the rise of modern science the causation of all complex physical phenomena was very poorly understood, and hence appeals to nonmaterial agencies (ghosts, sorcerers, demons, mythological beings) took the place of a causal, scientific explanation.
These results are consistent with the previous literature that emphasizes the importance of environmental factors on the causation of this complex disease [9], [10].
In general, results from computing more complex models suggested that fundamental causation of inflammation by structural disadvantage was occurring, in addition to potential independent influences on QoL from these same factors.
Such studies would maximize the chances of finding data patterns indicative of real etiology, although many aspects of complex disease causation might simply be too intricate and inconsistent to ever be deciphered.
