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The techniques developed in this paper are expected to be of value in "top down" synthesis of complex assembly of components as well as in synthesizing material microstructural arrangements to effect behavior at larger length-scales.
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The extensor mechanism of the human finger is a highly complicated musculoskeletal system with a complex assembly of multidirectional components with different viscoelastic properties.
Aircraft fuselages are complex assemblies of thousands of components and as a result simulation models are highly idealised.
Predicting the operating behaviour of a complex assembly including active components is a challenge, since accurate models of those components are rarely available.
In this respect it has been argued that flexibility favours the structural assembly of components of large complexes such as those involved in ribosome and therefore such characteristic should be prevalent in certain ribosomal proteins [ 38].
Biological process analysis showed that AS events occurred mainly in the processes of macromolecular complex assembly and cellular component organization.
In this paper, we propose two efficient algorithms for optimal allocation of tolerance among the components of complex assembly with large number of constraints and entities.
They included metabolic processes, cellular component assembly, biopolymer biosynthesis, macromolecular complex assembly, translation and regulation of many diverse processes.
In 1997, Bray and Lay [ 58] used modelling approach to analyse 30 different oligomeric complexes and found that disproportionally high concentration of one of the complex components may cause suppression of multimeric complex assembly.
Regarding ATP synthase (Complex V), ATP6 is a key component of the proton channel (FO component) and ATP8 seems to be a regulator of complex assembly (da Fonseca et al. 2008 ).
Such sequences may serve to stabilise poly(A) complex assembly by providing alternative binding opportunities for components of the 3′end processing machinery (Supplementary Figure 5).
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