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However, optimizing catalysis demands navigation through complex and rugged fitness landscapes, with optimization trajectories often leading to strong diminishing returns and dead-ends.
Mountain landscapes have complex and rugged topographies, with abrupt spatial and temporal changes in microclimate and soil properties, factors that directly affect tree growth and canopy processes.
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The ability to detect intermediates in simple, small proteins, including those that fold on rapid timescales, provides exciting opportunities to develop new insights into the intricacies of folding mechanisms by combining the power of experiments and simulation, as a prelude to tackling larger proteins for which the folding energy landscape will be more complex and more rugged.
For Wynwood she has been hand-crocheting covers for the large heavy boulders that dot the inner grounds of the complex in a blunt and rugged manner.
The cave complex used by ISIS was in a remote and rugged area of mountains and gorges.
However, it can represent a cutting edge for many laboratories, mainly because it requires a variety of complex techniques for properly characterizing metal nanoparticles with expensive and rugged equipment.
An assumption of our experimental model is that simple and complex resource environments correspond to adaptive landscapes that are "smooth" and additive, and "rugged" and epistatic, respectively.
Both are planar and rugged.
Thick and rugged.
Rough and rugged.
It's cheap and rugged and unpretentious.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com