In the hematopoietic system, very complex cooperative and antagonistic interplays between a considerable number of TFs, as well as timing of their expression, regulate the different lineage specifications from the hematopoietic stem cells [36] [38].
In practical ReRAM devices, multiple filaments may be formed and ruptured concurrently, which result in a much more complex behavior where antagonistic bipolar and unipolar switching occurs stochastically.
In addition, these sequences with a putative enhancer activity have not been tested in their natural context, which can be represented by clusters of several overlapping motifs with complex and often antagonistic interactions as already demonstrated for the CFTR gene [ 29].
However, exposures tend to be complex, containing both agonistic and antagonistic components.
Salicylic acid (SA), jasmonate (JA), and ethylene (ET) contribute to responses to biotic stresses by influencing various signalling pathways with complex networks of synergistic and antagonistic interactions [ 2].
The cytokine analysis constitutes an important part since they form a complex network of synergistic and antagonistic interactions which not only induce but also control immune response.
However, in the environment, organisms are exposed to complex mixtures of potentially synergistic and antagonistic compounds, and it is unknown how these chemicals interact in vivo and whether such interactions diminish or exacerbate their individual effects on the health of the organism.
The crosstalk between JA and ABA is complex, and either synergistic or antagonistic depending on the different regulatory mechanisms mediated by the two hormones.
The complex interplay of RBPs in agonistic and antagonistic modulation of mRNA is becoming increasingly apparent.
The relationship between these two genes is complex, with studies indicating both synergistic and antagonistic functions [ 11– 11].
