One week following the completion of treatment, tumour burden was analysed in all animals by quantifying fluorescent tumour colonies as described in the Materials and Methods.
Patients in the CDD cohort were recruited from the same study sites at which the Schedule 4/2 was analysed, after completion of enrolment in the Schedule 4/2 cohort and observation of the requisite number of responses on Schedule 4/2.
Internal validity was analysed by (i) Completion of questions and missing data: percentage completion by respondents in the surveys was calculated; (ii) Internal agreement within questions: levels of expected response combinations (as percentage) were calculated within each set of questions.
Correlations between independent variables – muscle mass, SPPB scores, age, gender, performance status and treatment receipt and successful completion will be analysed using logistic regression.
Scope of the Review Evaluation Findings The findings of this project completion review are analysed and organised in relation to standard OECD criteria of relevance, effectiveness, efficiency, impact, sustainability, gender equality, analysis and learning (M&E).
Between-treatment differences on quality of life scales (FACT-B, RSCL, HADS, and MRS) at the primary endpoint (3 weeks after completion of chemotherapy) were analysed using Analysis of Covariance (ANCOVA) (with pre-randomisation values as covariate).
After migration completion, the EGFR sequences were analysed using Applied Biosystems Sequencing Analysis version 5.2 software.
Background data will be analysed following completion of recruitment to ascertain homogeneity of the three groups.
Following the completion of interviews, the data were analysed using the Attride-Stirling thematic network analysis framework [ 41].
