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A thorough understanding of these differences and expertise in the conduct of pediatric-specific studies are required for the safe, ethical, and successful completion of translational studies in children.
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The cleavage of the propeptide to form the comparatively short mature peptide is often dependent on the completion of post-translational modifications, such as sequential enzymatic modification, glycosylation, glycosulfation or the pairing of S-S bonds.
For EmrE and its mutants, we find that a significant fraction of the IMP configurations are misintegrated upon completion of ribosomal translation and undergo subsequent post-translational annealing to reach fully integrated topologies.
Moreover, while the N-terminus N-glycans are required for the early stages of the folding process, the C-terminus are conditional for completion of its post-translational productive folding.
This work was supported by Bristol-Myers Squibb through a contract for completion of the clinical and translational investigation to the University of Chicago.
The prior completion of physiological development before our analysis could explain the downregulation of translational processes and ribosome biogenesis.
However the completion of a productive folding requires post-translational steps as previously reported [23], [25].
Center of Translational Biomedicine, Skolkovo Institute of Science and Technology, Skolkovo, Moscow, Russia.
Journal of translational medicine 15, 95 (2017).
Journal of translational medicine 12, 183 (2014).
Identification of ncRNAs in neuronal soma, the primary site of translational control, will further our understanding of translational control.
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