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This experimental model demonstrated that HBO is effective in reducing the long-term side effects of therapeutic radiation treatment in normal tissue, when given 1 week after the completion of the radiation treatment.
The patient's symptoms in the right eye had begun about 1 month following the completion of the radiation treatment for breast cancer, at which point she was diagnosed with nodular scleritis inferotemporally in the right eye, and she was found to have elevated perinuclear accentuated anti-neutrophil cytoplasmic antibodies (p-ANCA), leading to suspicion for granulomatosis with polyangiitis.
A prospective study was performed in an irradiated rat model to determine whether HBO is effective in reducing the long-term side effects of therapeutic radiation treatment on normal tissue, when given 1 week after the completion of the radiation treatment.
This positive interaction was greater when S44563 was given after the completion of the radiation, which might be explained by the radiation-induced overexpression of anti-apoptotic proteins secondary to activation of the NF- κB pathway.
In our study, we showed that using S44563 during fractionated irradiation increases the efficacy of radiation and that this effect was greater when S44563 was given after the completion of the radiation in SCLC.
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The results of a post-treatment gynecologic examination (under anesthesia, with or without biopsy) performed 3 months after completion of the entire radiation treatment and at least 12 months of documented follow-up.
(2) The results of a post-treatment gynecologic examination (under anesthesia, with or without biopsy) performed 3 months after completion of the entire radiation treatment and at least 12 months of documented follow-up.
The hematologic data - hemoglobin, total WBC count, neutrophil count, lymphocyte count, and platelet count - were taken before and after completion of the prescribed radiation dose.
The second time point for women in the WBRT group took place upon completion of the whole breast radiation therapy, approximately 7 weeks after the initial time point and for women in the PBRT upon completion of the partial radiation therapy, approximately 6 days after the initial time point.
The duration of time to locoregional failure and distant metastasis was measured from the date of the completion of radiation therapy (including boost irradiation) until documented treatment failure.
Three months after the completion of radiation therapy, the status of local control was investigated.
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