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At 4, 8, and 12 weeks after the completion of the dosing regimen, the animals (10 AOM-treated and 3 or 4 saline-treated rats per time point) were sacrificed by CO2 asphyxiation.
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Dulaglutide 1.5- and 0.75-mg doses were selected for further assessment at the completion of the dose-finding portion (18).
After completion of the dose-escalation study, the 46 h FU infusion dose was set at 2800 mg m−2 for patients receiving MdG alone, and 2400 mg m−2 for patients receiving OxMdG.
On completion of the dose-titration phase, patients in the full study entered a 4-week, double-blind, placebo-controlled, parallel-group phase and were randomized in a 1 1 ratio to receive either their maintenance dose of lanthanum carbonate (as determined in the dose-titration phase) or a matched dose of placebo.
A 2-dose schedule may also achieve improved compliance and completion of the total dosing at an earlier time point as it obviously requires fewer doses to obtain full vaccination compared with a 3-dose schedule [ 18].
Blood samples were collected prior to administration of the first vaccine dose and one month after completion of the 3-dose primary course.
As PPSV23 is generally recommended in HIV-infected individuals, one dose of PPSV23 was administered 1 month after completion of the three-dose series of PCV13.
13 14 Initiation of the HPV vaccine (ie, receiving at least one dose) has been shown to be higher among minority adolescent girls; however, completion of the three-dose series is substantially lower among African-Americans and Hispanics compared to Caucasians.
Similarly, the peak concentration taken 0.5 h after the infusion is stopped (4.68 mg/L) after the 5th dose is the same as that if it had been taken 0.5 h after the completion of the 4th dose.
And completion of the second dose of vaccination was a prerequisite for increased seropositivity.
The case-cohort and the case-control study designs produced the same VE point estimates for completion of the three dose series.
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