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Dulaglutide 1.5- and 0.75-mg doses were selected for further assessment at the completion of the dose-finding portion (18).
After completion of the dose-escalation study, the 46 h FU infusion dose was set at 2800 mg m−2 for patients receiving MdG alone, and 2400 mg m−2 for patients receiving OxMdG.
On completion of the dose-titration phase, patients in the full study entered a 4-week, double-blind, placebo-controlled, parallel-group phase and were randomized in a 1 1 ratio to receive either their maintenance dose of lanthanum carbonate (as determined in the dose-titration phase) or a matched dose of placebo.
At 4, 8, and 12 weeks after the completion of the dosing regimen, the animals (10 AOM-treated and 3 or 4 saline-treated rats per time point) were sacrificed by CO2 asphyxiation.
Similarly, the peak concentration taken 0.5 h after the infusion is stopped (4.68 mg/L) after the 5th dose is the same as that if it had been taken 0.5 h after the completion of the 4th dose.
And completion of the second dose of vaccination was a prerequisite for increased seropositivity.
The case-cohort and the case-control study designs produced the same VE point estimates for completion of the three dose series.
Completion of the three dose regimen was high and similar with both delivery systems (91.6% and 91.7% respectively).
Attendance and completion of the exposure dose was monitored by the instructor at each session.
The aforementioned efficacy estimates correspond to the first year starting 14 days after completion of the three dose regimen.
Median peripheral B-cell counts decline below normal following completion of the first dose, with recovery beginning after 6 months.
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