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The second-look surgery was performed within 1 year after the first surgery and after the completion of systemic adjuvant chemotherapy.
Definitive locoregional surgery (mastectomy n = 82, wide local excision n = 6) was performed on completion of systemic therapy (3-6 months).
Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer.
Uncertainties still remain about which sampling time (at baseline, during treatment, or at the completion of systemic treatment) could provide the most accurate prognostic information.
In addition, patients with CTC persistence after completion of systemic cytotoxic therapy are more likely to develop relapse compared with those who were CTC-negative [ 29, 30].
Indeed, the detection of CTCs before adjuvant chemotherapy as well as the persistence of CTCs after the completion of systemic adjuvant treatment is associated with an unfavorable clinical outcome [ 4- 6].
Similar(53)
Three weeks to 4 weeks after completion of the final cycle of systemic therapy, surgery and bone marrow aspiration were performed.
Change in ratings from pretest to 10 minutes after completion of nebulization (about 20 minutes after administration of systemic hydromorphone) indicated that each of the treatments resulted in statistically significant improvements in breathlessness, with no significant differences between treatments.
A wash out period to prevent any spill over of the ODNs into the systemic circulation followed the completion of the venous anastomosis before complete declamping.
Within group B, patients either received chemotherapy after completion of local treatment or no further systemic therapy at all.
Given the high rates of distant failure, the use of additional systemic therapy after completion of local treatment should be discussed.
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