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The authors recognize that since completion of enrolment in this study the definition of sepsis and septic shock has changed [18].
Patients in the CDD cohort were recruited from the same study sites at which the Schedule 4/2 was analysed, after completion of enrolment in the Schedule 4/2 cohort and observation of the requisite number of responses on Schedule 4/2.
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Completion of enrolments is planned for the middle of 2012.
After completion of patients' enrolment all analyses were re-calculated with stratification of patients according to the current standard criteria for treatment response [ 9].
Following completion of study enrolment, baseline measurements (T0) will be performed barefoot, with shoes only and with the subject's current orthosis (if applicable).
After the completion of the enrolment for this study in July 2012, we tightened the policy and aimed to commence the PN solutions includng the lipids within 2 hours of life.
Quality of data was ensured by regular telephone visits as well as by the monitoring visits at the sites conducted during or after completion of the enrolment at the site.
The mean (SD) and median intervals between completion of ReAct and enrolment in ReAlise were 5.5 (3.4) and 4.8 months, respectively.
Median time from completion of radiation to enrolment was 24 weeks (range 4 456 weeks) for the IFN study and 22 weeks (range 4 324 weeks) for the PEG study.
PCT levels were measured after the completion of all study enrolments, using a Time Resolved Amplified Cryptate Emission technology assay (TRACE®, Kryptor compact, PCTsensitive; Brahms AG; Hennigsdorf, Germany).
If military service causes a break in the educational career, it is likely that more time will be needed for completion of tertiary education and might therefore reduce the probability of enrolment and completion of tertiary education.
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