Sentence examples for completion of dosing from inspiring English sources
At the completion of dosing Morris water maze training was begun for one week using the same protocol as for the aged mouse study.
Blood specimens were collected in EDTA-coated vacutainer tubes before the administration of mapatumumab, and at the completion of dosing in cycles 1, 2, 3, and 6; at the time of disease assessment on or following the day 8 visit at cycles 3 and 6; and at a minimum of 28 days after the final dose of mapatumumab.
At higher doses of drug, however, 1 week after completion of dosing, creatinine and BUN levels had returned to levels that were higher than baseline.
After completion of dosing, eyes were thoroughly washed with normal saline and aqueous humor was aspirated at 2 h via paracentesis.
These increases in brain mitochondrial respiration relate to increased mtDNA gene expression (without detected changes in mitobiogenesis signaling genes), and in heart to increases in mitobiogenesis signaling genes (without detected changes in mtDNA gene expression assayed at the completion of dosing).
There was a minimum of at least 7 days between completion of dosing in one group and start of dosing in the next group to allow a satisfactory review of the safety and PK data from lower dose levels prior to progression to the next higher dose level [ 21].Six single oral dose levels of SMT19969 (2 to 2000 mg) or placebo were studied (Table 1).
PK evaluations were to be performed for single-dosing and multiple-dosing of which the dose levels were determined after completion of dose-escalation.
Three patients were enrolled per dose level until completion of dose-level 6 (65 mg m−2).
After completion of dose adaption, the individually titrated certoparin dose was to be used in subsequent dialyses.
3. Completion of dose response curve We thank the reviewers for this suggestion and have added the data as requested.
As no drug-related toxicity of >grade 2 had been observed by the completion of dose-level 6 (65 mg m−2), an accelerated dose-escalation scheme was adopted (Simon et al, 1997).
