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To prevent selective drop out of patients in poor health states, the questionnaires are designed to minimize completion burden.
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Following the pilot the reduced level of consent was introduced to enable the collection of clinical data about those who found questionnaire completion a burden.
Electronic forms of data collection may offer advantages in terms of speed of completion, decreasing patient burden and enhancing acceptability [ 56, 57].
As the median is considerably lower (20 minutes) and only 15% of subjects required more than 30 minutes for completion, the time burden was probably acceptable for most subjects.
A shortened version is used in this study to reduce the burden of completion and fatigue among participants completing the study questionnaire.
To reduce participant burden the completion of the various interview components will be staggered (Table 1).
Clinical outcomes were not predicted based on changes in sputum bacterial burden at completion of PEx treatment (Table 1).
Other studies show that increasing the length of a questionnaire results in an increased burden on completion and a decreased response rate [ 45- 48].
One week following the completion of treatment, tumour burden was analysed in all animals by quantifying fluorescent tumour colonies as described in the Materials and Methods.
Such data on burden of completion are important in evaluating the feasibility of these assessments in clinical studies of COPD and for the interpretation of results.
A recent review identified six commonly used questionnaires and concluded that the measures differ substantially in a number of aspects (conceptual and measurement model, reliability, validity, interpretability, burden of completion, administration format, validated translations) [ 6].
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