Furthermore, this review will discuss the nature of pattern separation and pattern completion and extend these processes outside the hippocampus and across all domains of information processing.
Along these lines, a role for mf synapses in pattern separation, in pattern completion, and in forming heteroassociative connections between discrete memory patterns has been proposed (McNaughton and Morris 1987; Treves and Rolls 1992; O'Reilly and McClelland 1994; Blum and Abbott 1996; Lee et al. 2004; Lisman et al. 2005).
CA3 retrieves coherent spatial representations from degraded dentate gyrus input: Direct evidence for pattern completion in CA3 and pattern separation in the dentate gyrus.
Past studies have reported that three factors delineate performance on the RCPM: continuous and discrete pattern completion, pattern completion through closure, and concrete abstract reasoning [ 23, 36, 37].
In high-resolution fMRI studies of humans, behavioral discrimination and completion tasks designed to approximate pattern separation and pattern completion, respectively, elicit the predicted pattern of activity in the dentate gyrus and CA3/CA1 [17–21].
Furthermore, it was constrained to perform pattern completion and separation under the effects of acetylcholine.
Numerous theoretical studies have revealed properties of attractor neural networks that make them a desirable neural mechanism for memory storage, such as robustness to damage, pattern completion, and generalization [11, 12].
There are also indications that other neurotransmitter systems may also be critically involved in the regulation of memory retrieval [3], [37], [45], [46], and it would be highly interesting to examine and compare their dynamic interactions between the partial cue-triggered pattern completion and the full cue-based memory retrieval.
Second, when animals are exposed to only partial novelty, they enable pattern completion and reinstatement of the original representation.
Our data suggest a unique and distinct function for CA3 synapses in spatial information processing that support a role for mf synapses in pattern completion and AC synapses in working memory and processing of information about novelty.
