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CXCR4 plays vital roles in HIV-1 life cycle for it's essential in mediating the interaction of host and virus and completing the entry process in the lifecycle of HIV-1 infection.
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Thus, the inability of these mutants to regulate their adhesive interactions likely results in their inability to complete the entry process.
Please see in the Results section: "These data point to an additional impairment in blood vessel entry, i.e. even when they do contact blood results in their inability to complete the entry process".
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By next year, when the United States should have completed its re-entry process, which includes a payment of $60 million, Americans will also be sought for recruitment.
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