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Forty and 79 patients entered period III (Reintroduction), with 40 and 77 completing period III.
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A total of 157/167 patients (94.0%) completed period I (Introduction); 120 (71.9%) qualified for period II (figure 2).
To enter period III, patients had to have been treated in (but not necessarily completed) period II.
A total of 1,284 participants were randomised into period I and received ≥1 dose of study drug (mITT analysis set); of 1,119 participants who completed period I, 1,103 entered period II and 1,020 completed 52 weeks of treatment (Fig. 1).
Furthermore, when information on the number of injections missed per 4-week period was completely missing, imputation analyses were performed using data from completed periods.
If a patient discontinued earlier than planned, ANOVA tests were only performed for his/her completed periods.
Patients were considered evaluable for toxicity if they experienced a DLT during the DLT-assessment period or completed this period with ⩾75% of the planned doses of saracatinib.
The company plans to expand to 300 or 350 employees by the end of next year completing a period of remarkably rapid growth.
Of 96 patients in the ipragliflozin group who entered treatment period 2, 90 completed this period.
In addition to a complete period rescaling scheme (CP), an operationally feasible real-time rescaling scheme (RT) is tested.
The complete period 1993.0 2009.0 was processed applying the free-network approach in order to estimate main parameters namely station and polar motion coordinates.
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