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Our patient developed progressive dyspnea shortly after completing induction therapy with cyclophosphamide followed by rituximab.
Patients without progressive disease were to have surgery within 6 weeks of completing induction therapy.
After completing induction therapy, patients were randomized to either MR every 3 months for 2 years or observation.
Many lymphoma patients present with residual masses after completing induction therapy, but less than 20% of them will eventually relapse.
However only the 98 patients completing induction therapy were evaluated for response rather than an intention-to-treat analysis being performed.
Our patient developed progressive dyspnea shortly after completing induction therapy with cyclophosphamide followed by rituximab, towards the end of the treatment of his M. abscessus infection.
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Among the 35 patients, 30 (85.7%) completed induction chemotherapy.
A total of 70 patients were enrolled between October 2005 and May 2008 and 69 completed induction therapy.
Three patients completed induction docetaxel, cisplatin and 5-fluorouracil (TPF) (two received three cycles, one received four cycles).
The observations of the induction phase were limited to the period between the patient's arrival in the OR to the anesthesia-ready time after completed induction.
A planned interim analysis (after 60 patients had completed Induction 1) revealed an apparent difference in time to recovery from severe neutropenia between the two treatment groups.
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