These results suggest that the completeness of protein interactions network plays a crucial role to identify high influence miRNAs.
All fields that are mandatory for data input as well as storage in the database are labeled by an asterisk, which ensures the completeness of expression and interaction data sets.
As is known, the reconstruction quality of the molecular genetic networks is related frequently to the problem of the completeness of information regarding the interactions between proteins.
Similarly, the determination of putative domain interactions depends on the quality and completeness of the underlying sets of protein interactions.
As can be seen from Figure 3 bottom panel, the pathway pairs we identified had a typical completeness of between-pathway synthetic lethal interactions at the range of [0.75, 0.85], which may have indication to the false-negative rate of the synthetic lethal interaction data (Text S2).
It can be expected that the combined use of programs based on different text-mining methods can increase the completeness of the description of the molecular interactions in the studied biological processes.
According to the assumptions in Figure 1A, if all possible pairs of genes between the two compensatory pathways are connected by synthetic lethal interactions, they have a completeness of 100%.
Determine level of interactions.
Be aware of interactions.
Through an evaluation of the completeness of current yeast and human protein-protein interaction networks, we propose that making raw unfiltered results available to all researchers could help distinguish between real and spurious interactions.
